sage decreases results of diazepam by pharmacodynamic antagonism. Minor/Importance Mysterious. Theoretical conversation; some species of sage may result in convulsions.
glucagon improves toxicity of scopolamine by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon enhance the danger of gastrointestinal adverse reactions as a result of additive results on inhibition of gastrointestinal motility. .
Diazepam doesn't increase or decrease hepatic enzyme exercise, and isn't going to alter the metabolism of other compounds. No proof would advise diazepam alters its individual metabolism with Persistent administration.[28]
Advise people and caregivers that likely lethal additive consequences may perhaps come about if diazepam is used with opioids and that this kind of drugs really should not be applied concomitantly Except if supervised by a overall health care company
Antegrade amnesia may perhaps occur applying therapeutic dosages, the danger growing at bigger dosages; amnestic effects might be linked to inappropriate actions
zafirlukast will increase the stage or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
miconazole vaginal will increase the level or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
stiripentol will lower the extent or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Intently. Contemplate lessening the dose of CYP2C19 substrates, if adverse reactions are knowledgeable when administered concomitantly with stiripentol.
diazepam will improve the amount or influence of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.
This pores and skin patch is applied to avoid nausea and vomiting due to motion sickness or recovery from anesthesia and surgical procedures. This medication performs by correcting the imbalance of normal substances (acetylcholine and norepinephrine) that will happen in movement sickness.
Benzodiazepine procedure ought to be discontinued without delay by a sluggish site web and gradual dose reduction routine.[19][seventy seven] Tolerance develops to your therapeutic results of benzodiazepines; as an example tolerance occurs into the anticonvulsant outcomes and Because of this benzodiazepines usually are not normally advised with the prolonged-time period management of epilepsy. Dose boosts might overcome the results of tolerance, but tolerance may well then create to the higher dose and adverse consequences may well raise.
dasatinib will enhance the stage or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Anaphylaxis, such as episodes of shock noted, next parenteral administration; keep an eye on for signs and indications of hypersensitivity reactions
Reserve concomitant prescribing of those drugs in patients for whom other treatment solutions are inadequate. Restrict dosages and durations for the minimum expected. Check carefully for indications of respiratory melancholy and sedation.